NATURAL PRODUCTS

Natural products are secondary metabolites and have multiple uses in the context of androgenetic alopecia (AGA), and their potential benefits in managing or treating this prevalent form of hair loss can be investigated. Data collection on natural products for androgenic alopecia aims to improve scientific understanding and potential treatment developments.

LIST OF NATURAL PRODUCTS USED FOR THE TREATMENT OF ANDROGENETIC ALOPECIA:-

ID	COMMON NAME	SCIENTIFIC NAME	FAMILY	CLIMATIC CONDITION	SMILES STRUCTURE	CAS	EXPERIMENTAL MODEL	CHEMICAL CONSTITUENT	REFERENCES	PHOTO
1	ALOE VERA	aloe barbadensis	Asphodelaceae	Hot, dry climates	C1=CC2=C(C(=C1)O)C(=O)C3=C([C@H]2[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C=C(C=C3O)CO	1415-73-2	Human dermal papilla cells	Contain phytochemicals under study for possible bioactivity such as acetylated, mannans, polymannans,anthraquinone Cglycosides, anthrones, and other anthraquinones, such as emodin and various lectins.	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330525/
2	ASHWAGANDHA	Withania somnifera	Solanaceae	sub-tropical climate	CC1=C(C(=O)O[C@H](C1)[C@@](C)([C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)O)C	30655-48-2	Cultured mink hair follicles Cultured dermal papilla cells Cultured outer root sheath cells	steroidal lactones that modulates cortisol level	Stephens TJ, Berkowitz S, Marshall T, Kogan S, Raymond I. A Prospective Six-month Single-blind Study Evaluating Changes in Hair Growth and Quality Using a Nutraceutical Supplement in Men and Women of Diverse Ethnicities. J Clin Aesthet Dermatol. 2022 Jan;15(1):21-26. PMID: 35309272; PMCID: PMC8903234.
3	AMLA FRUIT	Phyllanthus emblica	Phyllanthaceae	dry climate	C1C2C(C(=C(C(=O)O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C(=C5C6=C(C(=C(C=C6C(=O)O1)O)O)O)O)O)O	90028-28-7	Human follicle dermal papilla cells NIH3T3 cells Clinical Study	Emblicanin A and B	Akhbari M, Firooz A, Rahimi R, Shirzad M, Esmaealzadeh N, Shirbeigi L. The effect of an oral product containing Amla fruit (Phyllanthus emblica L.) on female androgenetic alopecia: A randomized controlled trial. J Ethnopharmacol. 2024 Jan 10;318(Pt A):116958. doi: 10.1016/j.jep.2023.116958. Epub 2023 Jul 23. PMID: 37487962.
4	SAW PALMATTO	Serenoa repens	Arecaceae	humid, subtropical to warm-temperate climate	CCC(CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)C(C)C	84604-15-9	Human keratinocyte cells, C57BL/6 mice	phytosterols (βsitosterol), fattyacids,ßcarotene,and polysaccharides	_Reesha_Baig_Priyanka_Goswami_Mohammad_Wais_Gaurang_Sawant_Shifa.pdf
5	PUMPKIN SEED OIL	Cucurbita pepo	Cucurbitaceae	warm,sunny climate.	CCC(CCC(C)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C)C(C)C.CCC(CCC(C)C1CCC2C1(CCC3C2=CCC4C3(CCC(C4C)O)C)C)C(C)C.CC(C)C(C)CCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C	8016-49-7	Dermal papilla and keratinoCytes	unsaturated fats,sterols or phytoestrogens and tocopherols	_Reesha_Baig_Priyanka_Goswami_Mohammad_Wais_Gaurang_Sawant_Shifa.pdf
7	ROSEMARY OIL	Rosemary oil	Lamiaceae	warm and moderately dry climate	CC(C)C1=C(C(=C2C(=C1)C3CC4C2(CCCC4(C)C)C(=O)O3)O)O	8000-25-7	Oleuropein	rosmarinic acid, caffeic acid, chlorogenic acid, carnosic acid,rosmanol, carnosol, ursolic acid, glycolic acid, and rosmaricine.	_Reesha_Baig_Priyanka_Goswami_Mohammad_Wais_Gaurang_Sawant_Shifa.pdf
8	CAPSICUM	CAPSICUM ANNUM	Solanaceae	moderately low temperatures and dry season	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CCO)C)C	8023-77-6	Human dermal papilla Cells	Carotenoids
9	COFFEE	CAMELLIA SINESIS	Rubiaceae	semi-tropical climate	[O-]P(=O)([O-])F.[Na+].[Na+]	84650-00-0	Culturedhair follicles Human hair-follicle-derived outer root sheath keratinocytes (ORSKs)	xanthine alkaloids	_Reesha_Baig_Priyanka_Goswami_Mohammad_Wais_Gaurang_Sawant_Shifa.pdf
10	LIQUORICE	GLYCYRRHIZA GLABRA	Fabaceae/ Leguminosae	dry cold temperature		68916-91-6	Dermal papilla cells	campesterol,glycyrrhizin,cholesterol, palmitic acid, linoleic acid, oleic acid, βsitosterol, stigmasterol, trigonellin, brassicasterol	_Reesha_Baig_Priyanka_Goswami_Mohammad_Wais_Gaurang_Sawant_Shifa.pdf
11	COCONUT OIL	Cocos nucifera	Arecaceae (palm family)	hot climate.	CN1CCC23C4C1CC5=C2C(=C(C=C5C(=O)O)OC)OC3C(C=C4)O	8001-31-8	Human keratinocyte cells /sunflower oil	myristic acid,capric acid, lauric acid and monolaurin
12	GARLIC GEL	Allium sativum	Amaryllidaceae	hot climate.	C=CC[S@](=O)C[C@@H](C(=O)O)N	8008-99-9	Randomized study	Alliinase,arginine,flavonoids,selenium	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9231528/
13	TEA TREE OIL	Melaleuca alternifolia	Myrtaceae	tropical and subtropical climates	C1=CC=[N+](C(=C1)[S-])[O-].C1=CC=[N+](C(=C1)[S-])[O-].[Zn+2]	68647-73-4	Double blind randomized study	terpinen-4-ol,γ-terpinene,8-cineole, α-terpinene, α-terpineol,p-cymene and α-pinene	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595365/table/?T1/report=objectonly
14	SIBERIAN CRANE'S-BILL	Geranium sibiricum	Geraniaceae	average to moist conditions		NA	Human dermal papilla Cells	Corilagin, gallic acid	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595365/table/T1/?report=objectonly,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706577/#B18-pharmaceutics-13-02163
15	SAFFLOWER	Carthamus tinctorius	Asteraceae	highmoist climate		8001-23-8	Dermal papilla and keratinoCytes	Hydroxysafflor yellow A	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8706577/#B18-pharmaceutics-13-02163
16	OLIVE	Olea europaea	Oleaceae	Mediterranean-like climate	C1=CC=C(C=C1)C(=O)NC2=C3C(=C4C(=C2)C5=CC(=C6C(=C5N4)C(=O)C7=CC=CC=C7C6=O)NC(=O)C8=CC=CC=C8)C(=O)C9=CC=CC=C9C3=O	8001-25-0	Oleuropein promoted cultured human follicle dermal papilla cell proliferation and induced LEF1 and Cyc-D1 mRNA expression and β-catenin protein expression in dermal papilla cells	Oleuropein	https://pubmed.ncbi.nlm.nih.gov/26060936/
17	SOFT SOPHORA	Sophora flavescens Aiton	Fabaceae	moderately low temperatures and dry season	C1[C@@H]2[C@H](C3=C(O1)C=C(C=C3)O)OC4=CC5=C(C=C24)OCO5	16837-52-8	Human dermal papilla Cells	L-maackiain medicarpin	https://www.jdsjournal.com/article/S0923-1811(02)00060-9/fulltext
18	BARLEY	Hordeum vulgare	Poaceae	subtropical climatic condition	C/C=C(C)/C(=O)OC1CCC2(C3C1(OC24CC5(C6CN7CC(CCC7C(C6(C(CC5(C4CC3)O)O)O)(C)O)C)O)O)C	85251-64-5	C57BL/6 mice	Procyanidin B-3	https://www.jdsjournal.com/article/S0923-1811(02)00060-9/fulltext
19	SHIKAKAI	Acacia concinna	Mimosaceae	Hot dry climates of Central Asia and the Far East	CCC(C=CC(C)C1CCC2C1(CCC3C2=CCC4C3(CCC(C4)O)C)C)C(C)C	202148-87-6	Human dermal papilla Cells	Lupeol spinasterol acacic acid lactone and the natural sugars glucose arabinose and rhamnose. It also contains hexacosanol spinasterone oxalic acid tartaric acid citric acid succinic acid ascorbic acid and the alkaloids calyctomine and nicotine	https://www.journalijar.com/uploads/256_IJAR-2736.pdf
20	PADDLE WEED	Ecklonia cava	Hydrocharitaceae	Halophytes	CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CO)OC(=O)C	NA	Cultured rat vibrissa folliclesSprague-Dawley rats C57BL/6 miceRat vibrissa immortalized dermal papilla cell NIH3T3 cells	Phlorotannins, such as fucodiphlorethol G, 7-phloro eckol, 6,6-bieckol, eckol, 8,8-bieckol, 8,4-dieckol and phlorofucofuroeckol A, DPC proliferation and/or 5α-reductase activity inhibition in rat vibrissa	Shin H Cho AR Kim DY Munkhbayer S Choi SJ Jang S Kim SH Shin HC Kwon O
21	REETHA	Sapindus mukorossi	Sapindaceae	warm cold climate	CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CO)OC(=O)C	223748-41-2	Human dermal papilla Cells	saponins sugars and mucilage	https://www.researchgate.net/publication/267698560_Sapindus_mukorossi_areetha_An_overview
22	TUBER FLEECEFLOWER	Polygonum multiflorum	Polygonaceae	Cold Climate	C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2=O		Human dermal papilla Cells,C57BL/6J mice were used	Athraquinones including chrysophanol emodin and rhein	Shin JY Choi YH Kim J Park SY Nam YJ Lee SY Jeon JH Jin MH Lee S. Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells, BMC Complement Med Ther. 2020 May 12;20(1):144. doi: 10.1186/s12906-020-02940-5. PMID: 32398000; PMCID: PMC7218528
23	FLAXSEED OIL	Linum usitatissimum	Linaceae	cool humid climate	C1=C(C(=CC(=C1Cl)Cl)Cl)O	8001-26-1	prostatic epithelial proliferation in a rat model of benign prostatic hyperplasia	phytochemicals like phenols flavonoids and lignins	https://ugro.com/a-research-perspective-on-flaxseed-oil-for-hair-loss/amp/
24	CURRY TREE	Murraya koenigii	Rutaceae	Humid subtropical climate	C1=CC=C2C(=C1)C3=CC=CC=C3N2	8006-78-8	activity of berry extracts of M. koenigii by DPPH free radical scavenging activity and reducing power assays	Different carbazole alkaloids and other important metabolites like terpenoids flavonoids phenolics carbohydrates carotenoids vitamins and nicotinic acid from different parts of the M. koenigii plant.Mahanine Mahanimbine	Balakrishnan R Vijayraja D Jo SH Ganesan P Su-Kim I Choi DK. Medicinal Profile Phytochemistry and Pharmacological Activities of Murraya koenigii and its Primary Bioactive Compounds. Antioxidants (Basel). 2020 Jan 24;9(2):101. doi: 10.3390/antiox9020101. PMID: 31991665; PMCID: PMC7070712
25	HORSERADISH OR DRUMSTICK TREE	Moringa oleifera	Moringaceae	Tropics and subtropics	CCO	93165-54-9	clinical study of 15 patients with urinary tract infection Maurya and Singh observed that 66.67% of patients were completely cured of their symptoms after a three-week treatment with M. oleifera bark extract while 13.33% reported moderate relief from their symptoms 13.33% of patients had no symptom change and 6.67% relapsed in the trial group	phytochemicals such as flavonoids or isothiocyanates	Kou X Li B Olayanju JB Drake JM Chen N. Nutraceutical or Pharmacological Potential of Moringa oleifera Lam. Nutrients. 2018 Mar 12;10(3):343. doi: 10.3390/nu10030343. PMID: 29534518; PMCID: PMC5872761